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Medical University of South Carolina UNIV - Post Doctoral Scholar - Biochemistry in Charleston, South Carolina

FLSA: Salaried

Job Summary: Dr. Delaney, PhD, has an opening in his laboratory for a self-motivated and independent Postdoctoral Scholar. Delaney Lab projects are centered on investigating how chromosomal copy number changes alter cell biology, particularly in the context of cancer using mice and cancer cell lines as model systems. We have developed bioinformatic algorithms to evaluate copy number alterations at an integrative and systems level, and use the informatics to prioritize which genes to study in a biological context. Our strongest success has been in evaluating the suppression of autophagy. We explore the molecular biology of interactions of autophagy and

genomic instability, as well as how to therapeutically take advantage of altered autophagy. The scientific culture in the lab is to initially design projects from unbiased genome-wide assays (bioinformatic or –seq technologies) and work out full stories from the outcome.

Payscale Salary Range: UNIV-Band 0: Commensurate with experience.

Job Duties:

  • 25% - Molecular biology assays, westerns, RT-qPCR, DNA isolation, microscopy - (Essential)

  • 20% - Cloning and subcloning of mouse and human genes using standard molecular biology techniques, DNA and RNA purification - (Essential)

  • 15% - Prepare cell culture samples by transfection and/or lentivirus - (Essential)

  • 15% - Perform mouse experiments, including tumor cell inoculation, chemotherapeutic treatment, dissections, histology, and related molecular biology - (Essential)

  • 10% - Participation in shared lab duties, i.e. reagent maintenance and inventory, general equipment/lab maintenance, data management - (Essential)

  • 7% - Scholarly activities- including manuscript preparation, poster and oral presentations at conferences. - (Essential)

  • 5% - Maintain mouse colony specific to project including genotyping and monitoring - (Essential)

  • 3% - Keep the lab organized and clean - (Essential)

Minimum Experience and Training Requirements:

Physical Requirements: Ability to perform job functions in an upright position. (Frequent) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb, using step stool. (Infrequent) Ability to work in temperature extremes (32? F to 100? F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent) Ability to work in confined/cramped spaces. (Continuous) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent) Ability to fully use both legs. (Frequent) Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent) Ability to maintain good olfactory sensory function/distinction. (Continuous) Ability to lift materials up to 20 lbs., unassisted. (Infrequent) Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent) Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent) Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/ Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent) Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent) Ability to push/pull file boxes from one location to another at floor level. (Frequent) Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to maintain 20/20 vision, corrected. (Continuous) Ability to match or discriminate between colors, normally. (Continuous) Ability to hear and recognize various alarms emitting from work area systems. (Continuous) Ability to hear and/or understand conversations. (Continuous) Ability to work in a darkroom for processing film, etc. (Continuous) Ability to be qualified physically for respirator use, initially and annually. (Continuous)

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